This patent portfolio covers foundational technologies for continuous, non-invasive remote monitoring of vital signs using wearable devices and advanced sensing algorithms. The inventions protect systems and methods for cuff-less blood pressure measurement based on Pulse Arrival Time (PAT), multi-parameter physiological monitoring—including ECG, SpO₂, respiratory rate, and heart rate—along with calibration techniques, predictive alerts, and ambient sensing capabilities. Designed to support continuous monitoring in home and clinical environments, these technologies enable improved patient comfort, early detection of adverse events, and seamless integration with telehealth and healthcare IT platforms via API-ready architectures. With applications across remote patient monitoring, eldercare, chronic disease management, and post-acute recovery, the portfolio represents core infrastructure IP for decentralized and data-driven healthcare delivery and presents a strong licensing or acquisition opportunity for medical device manufacturers, digital health platforms, and telemedicine providers.